Catheter Ablation of Cardiac Arrhythmias: Basic Concepts and by David J. Wilber M.D., Douglas L. Packer M.D., William G.
By David J. Wilber M.D., Douglas L. Packer M.D., William G. Stevenson M.D.
Radiofrequency Catheter Ablation of Cardiac Arrhythmias has been so generally up-to-date for its 3rd variation that the booklet now contains a new name: Catheter Ablation of Cardiac Arrhythmias: simple ideas and medical purposes. The editors deliver you 21 polished chapters, each one updating the basics and progressing to complex suggestions, supplying cutting-edge wisdom with hugely suitable fabric for knowledgeable electrophysiologists in addition to fellows in training.This streamlined new version features:• new editors, either generally released and leaders within the box of catheter ablation• 21 rather than 39 chapters, accomplished through targeting fundamental issues of huge curiosity and assimilating info from quite a lot of resources• Fewer authors, selected for his or her famous contributions to the subjects lower than dialogue, supplying a extra built-in and coherent method• Anatomic insights from best pathologist Siew Yen Ho, built-in with new details from imaging technologiesEach bankruptcy facing ablation of a particular arrhythmia positive aspects the author's own method of ablation of the arrhythmia, together with functional "how-to" information, and a overview of strength pitfalls. exchange ways and diversifications are succinctly summarized. unique figures and drawings illustrate particular techniques to enhance the usability of the e-book.
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Extra resources for Catheter Ablation of Cardiac Arrhythmias: Basic Concepts and Clinical Applications, Third Edition
Changes in nucleolar structure and inhibition of nucleolar function have been observed at temperatures ranging from 41 °C to 45 °C . Heating of cultured mammalian cells to 42–45 °C results in inhibition of DNA synthesis, as measured by reduced incorporation of tritiated thymidine into cellular DNA. Heat-induced inhibition of DNA synthesis appears to be caused by both a reduced initiation of DNA synthesis and depression of DNA chain elongation . Whether heat directly causes DNA damage is controversial .
The relationship between temperature, power, and lesion size is sometimes paradoxical [12,13]. In cases in which RF delivery is power-limited, the lesion size will be proportional to the temperature achieved. However, the delivered power becomes the dominant predictor of lesion size when the electrode–tissue interface temperature is held constant and the magnitude of convective cooling varies. A greater degree of convective cooling matched by a higher level of delivered power will yield larger lesions, as described below .
One can address this issue by increasing the amplitude of power delivery so that, despite a lower fraction of the total power being converted to heat at the catheter tip, the absolute magnitude of the RF power density and tissue heating at the catheter tip is sufficient to accomplish the ablation. However, if there is a limited magnitude of power available for the ablation, then smaller ablation lesions will be the result (Fig. 3) . 2 A finite-element analysis of the steady-state temperature distribution from radiofrequency ablation with a coil electrode 12 mm long.