Catecholamines and the Heart: Recent Advances in by H. Seller, J. Czachurski, K. Dembowsky (auth.), Prof. Dr. W.
By H. Seller, J. Czachurski, K. Dembowsky (auth.), Prof. Dr. W. Delius, Prof. Dr. E. Gerlach, Prof. Dr. H. Grobecker, Prof. Dr. W. Kübler (eds.)
An overseas Symposium "Catecholamines and the center" used to be held in Munich in may well 1981, which was once geared up in cooperation with the Council on Cardiac Metabolism of the foreign Society and Federation of Cardiology and with the Microcirculation operating workforce of the eu Society of Cardiology. It used to be the purpose of the organizers to judge during this Symposium the new advances made within the box of sympathetic keep an eye on of middle functionality. specific awareness was once given to neural sympathetic pathways, to mechanisms and outcomes of adrenoceptor stimulation and blockade in addition to to clinically suitable implications commonly concerning the value of catecholamines and of adrenoceptors in a number of center ailments. The vast scope was once lined in 34 papers provided by way of physiologists, pharmacologists and cardiologists in the course of a day assembly which used to be attended by way of a world viewers. This e-book contains all papers in addition to the discussions following every one presentation. to complete speedy ebook the manuscripts are released as submitted by way of the authors. The discussions have been edited utilizing the written questions and solutions of the discussants. The Symposium used to be generously subsidized by way of Astra chemical substances GmbH, Wedell Holstein, Germany, which therefore made attainable a truly fruitful alternate of data, principles and ideas among experts in a variety of disciplines. The organizers gratefully recognize this aid once more and want to thank Dr. T. Kreuzer, the consultant of Astra chemical substances, for his own engagement.
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Extra info for Catecholamines and the Heart: Recent Advances in Experimental and Clinical Research, 1st Edition
Biochemical studies give us information about heterogenicity of binding sites in a tissue but will not tell us whether or not the coexistence of receptor subtypes is due simply to heterogenicity of cell types within the tissue sample. The coexistence of f31- and f32-adrenoceptors may have several pharmacological and clinical implications. From a pharmacological point of view it must be pointed out that studies of the potency order of agonists or studies of inhibitory patterns of selective antagonists with one agonist only are not sufficient for the characterization of the f3-adrenoceptors of an organ.
Folkow B, Heymans C, Neil E (1965) Integrated aspects of cardiovascular regulation. In: Hamilton WF, Dow P (eds) Handbook of physiology circulation, vol. 3: Am Physiol Soc, Washingtoft, pp 1787-1823 10. Furchgott RF, Bursztyn P (1967) Comparison of dissociation constants and of relative efficacies of selected agonists acting on parasympathetic receptors. Am NY Acad Sci 144: 882-899 II. Hedberg A, Mattsson H (in press) Beta-adrenoceptor interaction of full and partial agonists in the cat heart and soleus muscle.
Corresponding to the maximal response to prenalterol, the increase of adenylate cyclase activity is slightly less than 10%. This level corresponds well with the adenylate cyclase activity on maximal stimulation with prenalterol. In accordance with the concept of spare receptors (30) there is no receptor-reserve for the partial agonist prenalterol. Out of a pharmacological point of view prenalterol would be characterized as a partial agonist with an intrinsic activity of 80%-90% whe~eas, out of a biochemical point of view, prenalterol may be classified as a partial agonist with less than 10% 24 4 intnnsic activIty or as a j3-antagonist since it has been shown that prenalterol inhibits isoprenaline activated adenylate cyclase [II].