Cancer Management in Man: Chemotherapy, Biological Therapy, by David G.I. Kingston (auth.), Boris R. Minev (eds.)

By David G.I. Kingston (auth.), Boris R. Minev (eds.)

This booklet represents a accomplished description and overview of the main up to date methods to melanoma administration. every one bankruptcy, ready through best uncomplicated researchers and clinicians, offers a close description of a selected process for melanoma administration. The chemotherapy component to the ebook is up to date to incorporate the latest medicines in addition to these at the moment in improvement. equipped by way of drug type, this part offers the most recent info on such a lot medications, together with their mechanisms of motion, interactions with different brokers, toxicities, unintended effects, and mechanisms of resistance. The organic remedy component to the booklet offers elevated assurance of the at present used cytokines, vaccines, and mobilephone dependent remedies of melanoma. complete attention can also be given to different glossy therapy methods, corresponding to tyrosine kinase inhibitors, inhibitors of tumor angiogenesis, and the transcatheter administration of melanoma. present advances in hyperthermia in melanoma therapy, hematologic and dietary help, bone marrow transplantation, soreness administration and care of the terminally ailing sufferers with melanoma also are provided. In precis, this booklet offers a finished assurance of the present wisdom at the so much leading edge, systematic and multidisciplinary ways to the therapy of sufferers with cancer.

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Extra resources for Cancer Management in Man: Chemotherapy, Biological Therapy, Hyperthermia and Supporting Measures

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The vinca alkaloids are routinely administered by direct intravenous injection. 8) so are often administered as a rapid bolus. Vinorelbine can be administered orally. 0 (mg/m2 ) due to substantial neurotoxicity reported at higher doses. However, significant interpatient variability exist, and some patients can tolerate much higher doses with limited toxicity [29, 30]. 7 mg/m2 for children and adults, respectively, with gradual dose escalation based on hematologic tolerance. Vinesine has been evaluated for weekly and biweekly administrations, and is most commonly administered at 2–4 mg/m2 every 7–14 days [27].

However, there is little evidence that prolonged infusions are more effective than bolus schedules. Vinorelbine is most commonly administered at a dose of 30 mg/m2 weekly or biweekly. It can be administered as a slow infusion or bolus, although evidence indicates decreased local venous toxicity with a bolus [31]. 5 Mechanisms of Resistance Resistance to the vinca alkaloids develops rapidly and can occur through alterations in numerous cell pathways. For chemotherapeutic agents, resistance is commonly due to decreased drug accumulation and retention within target tumor cells.

Creaven PJ (1982) The clinical pharmacology of VM26 and VP16–213. A brief overview. Cancer Chemother Pharmacol 7:133–140 36. Issell BF (1982) The podophyllotoxin derivatives VP16– 213 and VM26. Cancer Chemother Pharmacol 7:73–80 37. Issell BF, Muggia FM, Carter SK (eds) (1984) Etoposide (VP-16). Current status and new developments. Academic, New York 38. Loike JD (1982) VP16–213 and podophyllotoxin. A study on the relationship between chemical structure and biological activity. Cancer Chemother Pharmacol 7: 103–111 39.

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