Bone Resorption Volume 2 (Topics in Bone Biology) by Felix Bronner, Mary C Farach-Carson and Janet Rubin (Eds)

By Felix Bronner, Mary C Farach-Carson and Janet Rubin (Eds)

There's presently no unmarried booklet with brand new info on osteoclast functionality and bone resorption. an invaluable selection of details, no longer available in a focused and handy shape out there. offers a finished assessment of the sector.

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Additional resources for Bone Resorption Volume 2 (Topics in Bone Biology)

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Yao GQ, Wu JJ, Sun BH, Troiano N, Mitnick MA, Insogna K (2003) The cell surface form of colonystimulating factor-1 is biologically active in bone in vivo. Endocrinology 144:3677–82. Yasuda H, Shima N, Nakagawa N, Yamaguchi K, Kinosaki M, Mochizuki S, et al. (1998) Osteoclast differentiation factor is a ligand for osteoprotegerin/ Osteoclast: Origin and Differentiation osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL. Proc Natl Acad Sci USA 95:3597– 602. 207. Yeh W, Shahinian A, Speiser D, Kraunus J, Billia F, Wakeham A, et al.

Biochem J 192:365–8. Delaisse JM, Eeckhout Y, Vaes G (1984) In vivo and in vitro evidence for the involvement of cysteine proteinases in bone resorption. Biochem Biophys Res Commun 125:441–7. Delaisse JM, Eeckhout Y, Vaes G (1985) Bisphosphonates and bone resorption: effects on collagenase and lysosomal enzyme excretion. Life Sci 37:2291–6. Delaisse JM, Ledent P, Vaes G (1991) Collagenolytic cysteine proteinases of bone tissue. Cathepsin B, (pro)cathepsin L and a cathepsin L-like 70 kDa proteinase.

2001) Osteoprotegerin inhibits prostate cancerinduced osteoclastogenesis and prevents prostate tumor growth in the bone. J Clin Invest 107:1235–44. 2. Osteolytic Enzymes of Osteoclasts Merry Jo Oursler resorbed. It has therefore been of great interest to discover the identity and nature of the enzymes that execute bone resorption in the hope of targeting these enzymes to regulate rates of bone loss. The osteolytic roles of TRAP, cathepsins, and MMPs are discussed in the remainder of this chapter.

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