Bone Morphogenetic Proteins: From Laboratory to Clinical by David C. Rueger (auth.), Slobodan Vukicevic, Kuber T.

By David C. Rueger (auth.), Slobodan Vukicevic, Kuber T. Sampath (eds.)

From the elemental technological know-how to power and licensed medical purposes the latest info within the quickly growing to be box of bone morphogenetic proteins (BMPs) are summarized during this topical quantity. amazing scientists current experiences on a number of medical themes, together with biochemistry, biology, molecular biology and preclinical animal reports on spinal fusion, cartilage fix, craniofacial and dental reconstruction utilizing BMPs, in addition to licensed scientific functions in human bone non-unions.

This publication offers a source not just for specialists within the box, but additionally for undergraduate scholars, beginners and clinicians world wide, provided that using BMPs in orthopedic reconstruction has been already licensed in Europe, Australia, Canada and the USA.

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However, this was explained by the observations that prostate cancer cells were less sensitive to TGF-~ than their normal counterparts. Our data, showing a lack of expression of PDF in prostate cancer unresponsive to androgens suggest that in addition to a reduced sensitivity of prostate cancer to TGF-~ itself, in at least some cases prostate cancers may also down-regulate expression of other members of the TGF~ superfamily, thereby enhancing the potential for proliferation and subsequent metastases of prostate cancer cells.

__ I ___ _ - -- ~ _ .. _ _ _ _ - . 111M ' _ _ Figure 2 Expression of PDF in prostate cancer. RT-PCR analysis was used to confirm that PDF expression was not detectable in prostate cancer. Lanes 1-4 show data from the normal prostate the single band obtained by PCR corresponds to PDF. Lanes 5, 7, 9, and 11 contained RNA from prostate cancer. Lanes 6, 8, 12 contained RNA from hypertrophic prostate, whereas lane 10 contained RNA from normal prostate and lane 13 was empty. Corresponding PCR done for 185 ribosomal RNA showed no difference (data not shown).

Namely LNCaP and H660 express PDF, whereas all other cell lines switched off PDF expression where it fundions to regulate gene expression. 1 % ethanol) or DHT at a final concentration of 10-7 M in serum-free medium. After treatment, cells were scraped, frozen in liquid nitrogen and RNA prepared. Northern blot analysis was performed for PDF and 185 ribosomal RNA and the data expressed as fold increase in PDF expression as compared to vehicle following normalization to the 185 signal. 23 Vishwas M.

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