Atlas of Endometrial Histopathology by Gisela Dallenbach-Hellweg M.D., F.I.A.C., Hemming Poulsen

By Gisela Dallenbach-Hellweg M.D., F.I.A.C., Hemming Poulsen M.D. (auth.)

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71. Diffuse atrophy. H & E, x 100 Functional Disturbances Anovulatory Disturbances Fig. 72. 55 Diffuse atrophy. H & E, x 250 Distinction is possible when the histologic diagnosis is correlated with the clinical history, age of patient, hormone therapy, and basal body temperature curve. Postmenopausal bleeding is often associated with or even caused by endometrial atrophy due to breakage of atrophic vessels. Focal Pressure Atrophy Focal pressure atrophy (Figs. 73, 74) shows the same features as diffuse atrophy, but is localized, either overlying or facing a submucosal leiomyoma, whereas the surrounding endometrium may be quite different.

H & E, x 25 Fig. 71. Diffuse atrophy. H & E, x 100 Functional Disturbances Anovulatory Disturbances Fig. 72. 55 Diffuse atrophy. H & E, x 250 Distinction is possible when the histologic diagnosis is correlated with the clinical history, age of patient, hormone therapy, and basal body temperature curve. Postmenopausal bleeding is often associated with or even caused by endometrial atrophy due to breakage of atrophic vessels. Focal Pressure Atrophy Focal pressure atrophy (Figs. 73, 74) shows the same features as diffuse atrophy, but is localized, either overlying or facing a submucosal leiomyoma, whereas the surrounding endometrium may be quite different.

Clear cell metaplasia with occasional hobnail nuclei. H & E, X350 Stromal Metaplasia 47 stituents of the endometrium, only larger accumulations of these cells should be called metaplasia. Rare Forms of Metaplasia of Endometrial Glandular Epithelium Rare forms include clear cell metaplasia (Fig. 62), possibly derived from maldeveloped mucinous cells, and eosinophilic (oncocytic) metaplasia (Fig. 63). Such cells, however, may not always be truly metaplastic, but instead functional variations of glandular cells or cells in disturbed mitosis (see p.

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