Arterial Mesenchyme and Arteriosclerosis by Gardner C. McMillan (auth.), William D. Wagner, Thomas B.

By Gardner C. McMillan (auth.), William D. Wagner, Thomas B. Clarkson (eds.)

Presently, and some time past, the essential investigative emphasis between study staff in arteriosclerosis has been on plasma and arterial lipids. contemporary facts from a few laboratories recommend that arterial mesenchyme is of substantial significance within the pathogenesis and destiny of arteriosclerotic lesions. the importance of a few of those observations made it transparent that there has been want for intensified examine at the connective tissue elements of the arteriosclerotic lesion and that arteriosclerosis examine employees may benefit from a extra accomplished view of the topic. as a result of their event within the box of arteriosclerosis and their curiosity in stimulating new instructions for examine at the lesion, the Committee on Coronary Artery Lesions and Myocardial Infarctions of the Council on Arteriosclerosis, American middle organization, deliberate a global Workshop on Arterial Mesenchyme and Arteriosclerosis. The Workshop introduced jointly scientists professional in connective tissue examine and study on arteriosclerosis who provided the present prestige of data of their components of craftsmanship. The Workshop used to be held April 2-3, 1973 on the Royal Orleans inn, New Orleans, Louisiana and was once attended through greater than a hundred and seventy humans. The twenty papers and discussions awarded during this quantity summarize the complaints of the Workshop and symbolize a entire assessment of the function of arterial mesenchyme in arteriosclerosis.

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29 Circulation 34, 14. D. (1970). J. ), pp. 12-20. Springer-Verlag, New York. D. (197la). Hum. Pathol. 2, 1. D. (197lb). G. A. Gall, ed~), pp. 451-487. Macmillan, New York. , and Gottlob, R. (1968). Anat. Physiol. 345, 93. Jores, L. (1922). Virchows Arch. Pathol. Deut. Med. Wochenschr. 48, 649. Jores, L. (1924). In "Handbuch der Spezie11en Pathologischen Anatomie und Histologie". Band II, Herz und Gefasse (F. Henke and O. ), pp. 608-786. Julius Springer, Berlin. F. (1967). Amer. J. Pathol. 51, 681.

Invest. 14, 1764-1783). 20 JACK C. GEER AND WILLIAM S. WEBSTER fatty streak lesions. Foam cells are very abundant in some lesions and quite sparse in others. Modified smooth muscle cells vary in number depending on the depth of intima being observed. Modified smooth muscle cells are most prevalent near the lumen. Fig. 6. Human aortic plaque lesion. Portion of long and slender smooth muscle cell contains extensive profiles of granular endoplasmic reticulum and myofilaments adjacent to the plasma membrane.

1962) are of importance as they indicate that the specificity of the contributions by each of the three embryonic disc layers in general is not as rigid as was formerly believed and, specifically, that the mesenchyme is not derived exclusively from the mesoderm but from the ectoderm and perhaps even endoderm. , 1962). , 1962). The primitive mesenchymal cells are stellate with numerous processes of different sizes which contact intimately those of adjacent cells to form a network. Some investigators regard the mesenchyme as being largely syncytium in which the processes of adjacent mesenchymal cells are fused to form a protoplasmic continuity; most maintain that, while there is contiguity of the processes, there is no protoplasmic continuity.

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