Applied Fish Pharmacology by K. M. Treves-Brown MA, Vet MB (Cantab) (auth.)

By K. M. Treves-Brown MA, Vet MB (Cantab) (auth.)

As aquaculture maintains to extend there's a desire for higher wisdom of medicinal remedies either for the prevention and remedy of illness and for the commercial husbandry of fish. This e-book, the 1st of its sort, is written for a world readership. it's a reference handbook for someone eager about the choice of medications for management to fish. it's going to even be precious to directors focused on the felony regulate of aquaculture.
the 1st half covers concerns which have an effect on all medicine's tools of administering medications to fish, some of the points of protection and the correct laws in international locations with vital aquacultural industries. next components overview the variety of accessible medicinal ingredients and current present wisdom of the pharmacology and strategies of use for every. specific consciousness is given to issues of safety - for the fish, for the individual administering the drugs, for the patron of medicated fish and for the environment.

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5 DETERMINATION OF WITHDRAWAL PERIODS FOR FISH Given the MRL for a drug in any particular species, be it mammal, bird, fish or indeed invertebrate, the method of establishing the withdrawal period is the same. A large number of individuals are dosed at the proposed regimen; samples of them are slaughtered at intervals, and their tissues are assayed for the drug. The aim is to demonstrate a time point at which the levels in all tissues are below the MRL. It has generally been accepted that as few as four cattle may be assayed at any one time but that for poultry and fish ten or more are required.

The use of an alternative brand of what is apparently the same medicinal substance will probably infringe medicines law. e. excluding vaccines) relevant to fish. 2 shows the MA's granted at the time of writing for the use of medicinal products in fish in the EU member states with significant aquacultural industries. Furazolidone and dimetridazole used to be authorized in some member states, but now that these drugs have been consigned to Annex IV of Regulation 2377/90 these authorizations are automatically cancelled.

3 INJECTIONS As in mammals and birds so in fish some substances are irritant and can produce sterile abscesses in muscle, or adhesions following intraperitoneal injection. Fish differ from mammals and birds in that substances are absorbed from intramuscular injections rather slowly. Injection site abscesses are uncommon in fish because injections are usually done in air and air-borne bacteria are rarely pathogenic to fish. However when abscesses are formed and rupture the lesions are a hazard to osmo-regulation.

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