Adrenal Actions on Brain by Bruce S. McEwen (auth.), Dr. Detlev Ganten M.D., Ph.D., Dr.

By Bruce S. McEwen (auth.), Dr. Detlev Ganten M.D., Ph.D., Dr. Donald Pfaff Ph.D. (eds.)

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Adv Biochem Psychopharmacol 15 :251-265 Sze PY, Neckers L, Towle AC (1976) Glucocorticoids as a regulatory factor for brain tryptophan hydroxylase. J Neurochem 26: 169-173 Taxi J (1979) The chromaffin and chromaffin-like cells in the autonomic nervous system. Int Rev CytoI57:283-343 Teillet MA, Cochard P, LeDouarin NM (1978) Relative roles of the mesenchymal tissues and of the complex neural tube-notochord on the expression of adrenergic metabolism in neural crest cells. Zoon 6: 115 -122 Teitelman G, Joh TH, Reis DJ (1978) Transient expression of a noradrenergic phenotype in cells of the rat embryonic gut.

1972). Glucocorticoids may also modulate this induction. Increasing sympathetic activity by short-term cold stress induced higher TH levels in the adrenal medulla as early as the first few postnatal days. On the other hand, TH inducibility in the superior cervical ganglion did not appear until P15-20 (Otten and Thoenen 1975). The differential time of onset of inducibility in the ganglion and the adrenal correlates with the age at which local corticosteroid levels rise in these structures. Furthermore, pretreatment of P9 animals with dexamethasone makes possible cold stress TH induction in the ganglion at this early age (Otten and Thoenen 1975).

1 Early Delayed Feedback . . . . . . . . . . . . . . . . 2 Late Delayed Feedback . . . . . . . . . . . . . . . .. 5 Sites of Action in Feedback Inhibition . . . . . . . . . . . . 1 Fast Feedback . . . . . . . . . . . . . . . . . . .. 1 Anterior Pituitary . . . . . . . . . . . . . . . .. 2 Hypothalamus. . . . . . . . . . . . . . . . .. 3 Neural Pathways to the Hypothalamus . . . . . . . . ..

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