Acute Pulmonary Embolism: A Challenge for Hemostasiology by N. W. März, M. Nauck, H. Wieland (auth.), Dr. A. Geibel,

By N. W. März, M. Nauck, H. Wieland (auth.), Dr. A. Geibel, Prof. Dr. H. Just, Dr. med. W. Kasper, Dr. S. Konstantinides (eds.)

The worth of echocardiography within the diagnostic work-up of sufferers with suspected acute pulmonary embolism.- New advancements within the thrombolytic remedy of venous thrombosis.- Mechanism of blood coagulation. more recent facets of anticoagulant and antithrombotic therapy.- MR-angiography within the prognosis of pulmonary embolism.- Scintigraphy-ventilation/perfusion scanning and imaging of the embolus.- scientific direction and diagnosis of acute pulmonary embolism.- The molecular mechanisms of inherited thombophilia.

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Frosst P, Blom HJ, Milos R, Goyette P, Sheppard CA, Matthews RG, Boers GJ, den Heijer M, Kluijtmans LA, van den Heuvel LP, Rozen R (1995) A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase [letter]. Nat Genet 10: 111-3 40. Gandrille S, Borgel D, Ireland H, Lane DA, Simmonds R, Reitsma PH, Mannhalter C, Pabinger I, Saito H, Suzuki K, Formstone C, Copper DN, Espinosa Y, Sala N, Bernardi F,Aiach M (1997) Protein S deficiency: A database of mutations.

Among selected thrombophilic patient groups reported prevalences are difficult to compare, because different inclusion critieria have been used. However, protein e, protein S, and antithrombin III deficiencies combined Clinical implications of the new understanding of thrombophilia account for roughly 5 to 10 % in these patient groups and APC-resistance for approximately 50 % [5,15,47,96,106]. 8 % of young thrombophilk patients [37]. Only few studies exist on the prevalence of antiphospholipid antibodies in patients with venous thromboembolic disease.

Among selected thrombophilic patient groups reported prevalences are difficult to compare, because different inclusion critieria have been used. However, protein e, protein S, and antithrombin III deficiencies combined Clinical implications of the new understanding of thrombophilia account for roughly 5 to 10 % in these patient groups and APC-resistance for approximately 50 % [5,15,47,96,106]. 8 % of young thrombophilk patients [37]. Only few studies exist on the prevalence of antiphospholipid antibodies in patients with venous thromboembolic disease.

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