Acute Leukemias VI: Prognostic Factors and Treatment by J. D. Rowley (auth.), Prof. Dr. T. Büchner, Prof. Dr. G.

By J. D. Rowley (auth.), Prof. Dr. T. Büchner, Prof. Dr. G. Schellong, Prof. Dr. J. Ritter, Priv. Doz. Dr. U. Creutzig, Prof. Dr. W. Hiddemann, Priv. Doz. Dr. B. Wörmann (eds.)

For 10 years the publication sequence Acute Leukemias has been delivering updates at the quick development being made the world over touching on this team of illnesses. The 5th quantity commonly addressed experimental ways, however the current factor provides either healing and prognostic points of the newest effects from significant multicenter medical trials. extra chapters document new traits in leukemia mobilephone biology,the tracking of minimum residual illness, and secondary leukemias, in addition to new antileukemic medications, antimicrobial innovations, and using cytokines. The mixed efforts opposed to acute leukemias defined during this e-book clarify the new advancements within the end result of sufferers struggling with acute leukemias.

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We have investigated whether cells with a stem cell-like immunophenotype (CD34+/CD38-) are involved in the leukemogenic process. In 12 patients with AML and in one patient with MDS the identification of (pre)leukemic cells was performed by classical cytogenetics. Highly purified (96-98% purity) cellular subpopulations were generated by fiuoresence activated cell sorting according to the expression of CD34 and CD38. Following brief incubation with a cytokine cocktail (EPO, GCSF, GM-CSF, IL-3, SCF) the sorted subpopulations were processed for chromosome analysis.

21 + 8/+ 8. + 21 -1 +9 + 221 + 13,+ 22 - 1+22 -1 + 22 - It(2; 13)(p24;q 14) t(3; 17)(p 23;q21 - 23). 000 l) t( ,. ,1 )il )( 6 Unknown in 1st CR Alive 20 + Alive 35 + Alive 38 + Dead 3 Dead 5 Alive 9 + Alive 74 + Dead 7 Dead 7 Alive 19 + Alive 79 + Dead 3 It Ir 3 2 Pulmonary insufficiency Persistence ofleukemia Outcome. months ¢ . 16 r 17 5 12 "(. 18 XY 22 Fig. I. +21 chromosome aberrations might turn out to be of prognostic value. Acknowledgments. We thank PD Dr. Wandt, Klinikum der Stadt Nurnberg, Dr.

2. 6 2: :::I (f) c:: ~ & e (L ............... 1 0 0 10 20 30 50 60 70 80 90 100 110 120 Survival time in months Fig. 3. Outcome of 51 patients with inv(l6). The continuous line represents the survival of 39 patients with inv(l6) as the sole anomaly at initial diagnosis; the dashed line marks the survival of 12 patients who showed clonal chromosome aberrations in addition to inv(l6) technical assistance of N. Erbe, U. Kolbus, U. Koop, B. Hiischler and P. Muller is gratefully acknowledged. References I.

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